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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets

Author(s): Kamlesh Sharma*

Volume 18 , Issue 14 , 2017

Page: [1676 - 1686] Pages: 11

DOI: 10.2174/1389450117666160823165004

Price: $65

Abstract

Background: Protein farnesyltransferase (PFT) inhibitors have emerged as a potent target for the malaria treatment caused by the Plasmodium falciparum (Pf) parasite.

Objective: To explore the various scaffolds which are active against Pf-PFT target.

Result: Seven inhibitor scaffolds based on ethylenediamine, peptidomimetic, benzophenone, benzamide, tetrahydroquinoline, naphthyridine and oxy-tetrahydroquinoline, have been developed till date.

Conclusion: It is concluded that naphthyridine based drugs are the most promising one. Furthermore, introducing the hydrophobic molecules like isoprenyl groups to a protein or a chemical compound facilitate protein-protein and protein-membrane interactions thereby makes them good candidates as new therapeutics. The future research should focus on the disease rather than the infection and the dynamics of its transmission; this will bring a new vision about the disease.

Keywords: Plasmodium falciparum, antimalarial, protein, farnesyltransferase, inhibitor.

Graphical Abstract

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