摘要
变异的炎症会对正常组织产生严重的损害,从而导致多种病理状态如自身免疫失调,神经退行性疾病和癌症。治愈炎症相关的疾病是一个很大的挑战,传统上认为,草药是有效的抗炎治疗的最佳选择。本综述将全面阐述关于不同通路,结果以及炎症治疗策略方案的选择,主要集中于那些道地的抗炎草药化合物及其结构还有作用机制。超过100种的有科学报道的草药具有抗炎性。不同部位,比如根、茎、树皮、叶、花和种子 的活性化合物都有潜在的抗炎性。这样的化合物在炎症反应通路作为多靶标,以及调节多种化学介质,酶,基因或细胞功能来缓解炎症反应。尽管已经有了许多抗炎的天然化合物被分离出来了,但是其机制未能得到很全面的解释。此外,我们还需要执行优化好的临床试验,从而这些潜在的化合物能够在未来被用作治疗炎症的药品。
关键词: 自由基;炎症;标记物; 癌症;药物成分;炎症通路。
Current Medicinal Chemistry
Title:Inflammation: A Multidimensional Insight on Natural Anti-Inflammatory Therapeutic Compounds
Volume: 23 Issue: 33
Author(s): Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Akbar Masood, Mohammad Afzal Zargar, Showkat Ahmad Ganie
Affiliation:
关键词: 自由基;炎症;标记物; 癌症;药物成分;炎症通路。
摘要: Derailed inflammation causes severe damage to the normal tissues resulting in various pathological conditions such as auto-inflammatory disorders, neurodegenerative diseases and cancer. Cure of inflammatory diseases is a big challenge. Medicinal herbs used traditionally represent the best option for obtaining effective anti-inflammatory therapeutics. Present review provides a thorough insight about various pathways, consequences and therapeutic strategies of inflammation with prime focus to expose indigenous anti-inflammatory herbal compounds along with their structures and diverse range of mechanisms of action. Over hundred medicinal plants with scientifically reported anti-inflammatory properties were reviewed. Different parts of the plants like roots, stem, bark, leaves, flowers and seeds contain active compounds with potential anti-inflammatory properties. Such compounds act at multiple targets in the inflammatory response pathways and regulate multitude of chemical mediators, enzymes, genes or cellular functions to alleviate inflammation. Although a large number of antiinflammatory herbal compounds have been isolated but the mechanism of action of bulk of compounds has not been elucidated comprehensively. Besides there is need for conducting well designed clinical trials so that the promising compounds could be used as effective antiinflammatory therapeutic agents in future.
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Cite this article as:
Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Akbar Masood, Mohammad Afzal Zargar, Showkat Ahmad Ganie , Inflammation: A Multidimensional Insight on Natural Anti-Inflammatory Therapeutic Compounds, Current Medicinal Chemistry 2016; 23 (33) . https://dx.doi.org/10.2174/0929867323666160817163531
DOI https://dx.doi.org/10.2174/0929867323666160817163531 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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