Abstract
In this present study Aspirin loaded alginate nanoparticles were prepared by desolvation technique using acetone and ethanol as desolvating agents. Continuous and intermittent addition methods were adapted for the addition of desolvating agent to the aqueous solution. Two formulations were prepared by using each desolvating agent. F1 and F3 were prepared by continuous addition of acetone and ethanol as desolvating agents. F2 and F4 were prepared by intermittent addition of acetone and ethanol as desolvating agents. In all the Formulations, particles were found to be nanometric in size. Comparative study was made among these four Formulations for particle size, Mean particle diameter, Product yield, Drug content,Electrophoretic mobility, Zetapotential, Entrapment efficiency, Loading capacity. Dissolution studies were performed for all the four formulations and compared for better dissolution profile. Comparative study was made to determine the most appropriate desolvating agent and best method for the preparation of alginate nanoparticles. Among all Formulations Intermittent addition of ethanol was showing better result with Mean particle diameter of 237.4 nm, Entrapment efficiency of 37.4 %, Loading capacity of 10.22 %. The Zeta potential value (-52.3) was higher than all other Formulations. Based on these results it was concluded that intermittent addition method was the best method and ethanol was the better desolvating agent for the preparation of aspirin nanoparticles.
Keywords: Aspirin loaded, alginate nanoparticles, desolvation technique, acetone, ethanol, desolvating agents.
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