Abstract
Candida species are the major opportunistic human pathogens accounting for 70-90% of all invasive fungal infections. Candida spp, especially C. albicans, are able to produce and secrete hydrolytic enzymes, particularly aspartic proteases (Saps). These enzymes production is an evolutionary adaptation of pathogens to utilize nutrients and survive in host. Sap1-10 are believed to contribute to the adhesion and invasion of host tissues through the degradation of cell surface structures. Aspartic proteases control several steps in innate immune evasion and they degrade proteins related to immunological defense (antibodies, complement and cytokines), allowing the fungus to escape from the first line of host defense. The existing ways to identify potential drug targets rely on specific subset like virulence genes, transcriptional and stress response factors. Candida virulence factors like Sap isoenzymes can be pivotal targets for drug development. The identification of mechanism of a non-canonical inflammasome exerted by Saps could open novel therapeutic strategies to dampen hyperinflammatory response in candidiasis.
Keywords: Candida, Sap1-10, inhibitors, pathogenesis, fungal infections, enzymes.
Current Protein & Peptide Science
Title:Contribution of Aspartic Proteases in Candida Virulence. Protease Inhibitors against Candida Infections
Volume: 18 Issue: 10
Author(s): Staniszewska Monika*, Bondaryk Małgorzata and Ochal Zbigniew
Affiliation:
- National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw,Poland
Keywords: Candida, Sap1-10, inhibitors, pathogenesis, fungal infections, enzymes.
Abstract: Candida species are the major opportunistic human pathogens accounting for 70-90% of all invasive fungal infections. Candida spp, especially C. albicans, are able to produce and secrete hydrolytic enzymes, particularly aspartic proteases (Saps). These enzymes production is an evolutionary adaptation of pathogens to utilize nutrients and survive in host. Sap1-10 are believed to contribute to the adhesion and invasion of host tissues through the degradation of cell surface structures. Aspartic proteases control several steps in innate immune evasion and they degrade proteins related to immunological defense (antibodies, complement and cytokines), allowing the fungus to escape from the first line of host defense. The existing ways to identify potential drug targets rely on specific subset like virulence genes, transcriptional and stress response factors. Candida virulence factors like Sap isoenzymes can be pivotal targets for drug development. The identification of mechanism of a non-canonical inflammasome exerted by Saps could open novel therapeutic strategies to dampen hyperinflammatory response in candidiasis.
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Cite this article as:
Monika Staniszewska *, Małgorzata Bondaryk and Zbigniew Ochal, Contribution of Aspartic Proteases in Candida Virulence. Protease Inhibitors against Candida Infections, Current Protein & Peptide Science 2017; 18 (10) . https://dx.doi.org/10.2174/1389203717666160809155749
DOI https://dx.doi.org/10.2174/1389203717666160809155749 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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