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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Review Article

Drug Delivery From Hydrogels: A General Framework for the Release Modeling

Author(s): Diego Caccavo, Sara Cascone, Gaetano Lamberti, Anna Angela Barba and Anette Larsson

Volume 14 , Issue 2 , 2017

Page: [179 - 189] Pages: 11

DOI: 10.2174/1567201813666160808102106

Price: $65

Abstract

The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel- Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components.

Keywords: Controlled drug delivery, hydrogels, mathematical modeling, siRNAs.

Graphical Abstract

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