摘要
这个小型的文章摘要提供了一个使用磁性物质指导生物标志物分析的概观。特别是,磁性固定相萃取提供的优势,将在以下几个例子中讨论,同时考虑了非目标分析的筛选新蛋白质生物标记物和在已知目标的调查和新生物标志物建议。一方面说,富集效应比传统的技术,使用方便,通用性和自动化功能将被考虑,结合通过耦合选择性或特异性富集到强大的表征技术提供了量化和更深层次的结构鉴定,如质谱法。
关键词: 磁珠,磁性固定相萃取,蛋白质生物标记,新材料,生物标志物富集,生物标志物定量。
Current Medicinal Chemistry
Title:Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers
Volume: 24 Issue: 5
关键词: 磁珠,磁性固定相萃取,蛋白质生物标记,新材料,生物标志物富集,生物标志物定量。
摘要: This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.
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Cite this article as:
Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers, Current Medicinal Chemistry 2017; 24 (5) . https://dx.doi.org/10.2174/0929867323666160805121905
DOI https://dx.doi.org/10.2174/0929867323666160805121905 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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