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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Practical and Efficient Large-Scale Preparation of 4-Methylnicotinic Acid

Author(s): Zhaoxue Yu, Fei Sha and Peng Wang

Volume 13, Issue 6, 2016

Page: [450 - 452] Pages: 3

DOI: 10.2174/1570178613666160728154935

Price: $65


An efficient process for the large-scale synthesis of 4-methylnicotinic acid is developed. The synthetic route utilized 2,6-dichloro-4-methylnicotinonitrile as the starting material, which was commercially available. The key step in the sequence was the reductive dechlorination in the presence of zinc and ammonia to provide an intermediate which was hydrolyzed to the described acid. The reaction parameters optimization and improvement of purification are also presented. This approach, suitable for batch processing, is of interest basically to research laboratories and also to suppliers in the research and fine chemicals market.

Keywords: 4-Methylnicotinic acid, dechlorination, synthesis.

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