Abstract
The recognition of a foreign protein (antigen) by host B and/or T cells and the induction of immune response have a key role for the human immune system. The peptide binding to MHC proteins is a prerequisite for B or T-cell recognition. Determining the peptide-binding preferences exhibited by the MHC extensive set of alleles requires enormous experimental work. A more rational approach is the development of bioinformatics prediction methodologies. Among others, proteochemometrics (PCM) is quite suitable for MHC binding prediction as it simultaneously models the bioactivity of multiple ligands against multiple protein targets. Handling multiple targets is the key to "ligand polypharmacology" and the development of multi-target drugs. The few applications of PCM for MHC binding prediction showed that the developed models have excellent predictive ability
Keywords: Immunoinformatics, proteochemometrics, HLA-DRB1, HLA-DQ, peptide binding, MHC binders.
Letters in Drug Design & Discovery
Title:Proteochemometrics for the Prediction of Binding to the MHC Proteins
Volume: 14 Issue: 1
Author(s): Ventsislav Yordanov, Ivan Dimitrov and Irini Doytchinova
Affiliation:
Keywords: Immunoinformatics, proteochemometrics, HLA-DRB1, HLA-DQ, peptide binding, MHC binders.
Abstract: The recognition of a foreign protein (antigen) by host B and/or T cells and the induction of immune response have a key role for the human immune system. The peptide binding to MHC proteins is a prerequisite for B or T-cell recognition. Determining the peptide-binding preferences exhibited by the MHC extensive set of alleles requires enormous experimental work. A more rational approach is the development of bioinformatics prediction methodologies. Among others, proteochemometrics (PCM) is quite suitable for MHC binding prediction as it simultaneously models the bioactivity of multiple ligands against multiple protein targets. Handling multiple targets is the key to "ligand polypharmacology" and the development of multi-target drugs. The few applications of PCM for MHC binding prediction showed that the developed models have excellent predictive ability
Export Options
About this article
Cite this article as:
Yordanov Ventsislav, Dimitrov Ivan and Doytchinova Irini, Proteochemometrics for the Prediction of Binding to the MHC Proteins, Letters in Drug Design & Discovery 2017; 14 (1) . https://dx.doi.org/10.2174/1570180813666160630122341
DOI https://dx.doi.org/10.2174/1570180813666160630122341 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nicotinic Receptors Containing the α7 Subunit: A Model for Rational Drug Design
Current Medicinal Chemistry Heparanase Inhibitors Facilitate the Assembly of the Basement Membrane in Artificial Skin
Current Tissue Engineering (Discontinued) Development of Genetic Testing for Breast, Ovarian and Colorectal Cancer Predisposition: A Step Closer to Targeted Cancer Prevention
Current Drug Targets Drug Targeting of Estrogen Receptor Signaling in the Cardiovascular System: Preclinical and Clinical Studies
Current Medicinal Chemistry - Cardiovascular & Hematological Agents The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis
Current Cancer Drug Targets Fluoroquinolone and Ovariectomy in the Bitch: Physiology of the Immune System as to CD56 and CD16 Expression
Endocrine, Metabolic & Immune Disorders - Drug Targets Evaluation of the in vitro Chemosensitivity and Correlation with Clinical Outcomes in Lung Cancer using the ATP-TCA
Anti-Cancer Agents in Medicinal Chemistry Innate T-Cell Immunity in HIV Infections: The Role of Vg9Vd2 T Lymphocytes
Current Molecular Medicine Phospholipid Nanosomes
Current Drug Delivery Recent Developments on Thiourea Based Anticancer Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry The Endoplasmic Reticulum Alpha-Glycosidases as Potential Targets for Virus Control
Current Protein & Peptide Science Recent Clinical Advances in the Treatment of Cutaneous Melanoma
Clinical Cancer Drugs Progress in Topical siRNA Delivery Approaches for Skin Disorders
Current Pharmaceutical Design The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
Current Genomics Incidental Extracardiac Findings on Coronary Computed Tomography Angiography: A Pictorial Review of Imaging Findings
Current Medical Imaging The Role of Microbial Agents in the Etiology of Schizophrenia: An Infectious Hypothesis for Psychosis?
Current Immunology Reviews (Discontinued) Role of Central and Peripheral CRH in Skin
Current Molecular Pharmacology Attempted Cell Cycle Induction in Post-Mitotic Neurons Occurs in Early and Late Apoptotic Programs Through Rb, E2F1, and Caspase 3
Current Neurovascular Research Anticancer Agents Derived from Natural Products
Mini-Reviews in Medicinal Chemistry Structural Magnetic Resonance Imaging Findings in Posttraumatic Stress Disorder and Their Response to Treatment: A Systematic Review
Current Psychiatry Reviews