Abstract
Mesenchymal stem cells are spindle-like plastic adherent multipotent cells that can differentiate into multiple specialized cell types including osteoblasts, chondrocytes and adipocytes. They were isolated from many tissues and organs and they contribute to the maintenance and regeneration of several tissues. Besides their ability of self-renewal, they have recently been shown to have a clinical/therapeutic potential particularly for their immunomodulatory properties. Indeed recent studies suggested a potential application of MSCs for the treatment of experimental autoimmune disorders. It was demonstrated that their effects are in part mediated by the release of soluble factors or extracellular vesicles, including exosomes and microvesicles, stimulating or inhibiting target cells. This review will describe the secretome of MSCs, pointing the attention on the components relevant for their immunodulatory activities.
Keywords: Mesenchymal Stem Cells, Secretome, Soluble Factors, Immunomodulation, Extracellular Vesicles, Exosome.
Current Medicinal Chemistry
Title:The Immunoregulatory Activity of Mesenchymal Stem Cells: ‘State of Art’ and ‘Future Avenues’
Volume: 23 Issue: 27
Author(s): Alessandra Fierabracci, Andrea Del Fattore and Maurizio Muraca
Affiliation:
Keywords: Mesenchymal Stem Cells, Secretome, Soluble Factors, Immunomodulation, Extracellular Vesicles, Exosome.
Abstract: Mesenchymal stem cells are spindle-like plastic adherent multipotent cells that can differentiate into multiple specialized cell types including osteoblasts, chondrocytes and adipocytes. They were isolated from many tissues and organs and they contribute to the maintenance and regeneration of several tissues. Besides their ability of self-renewal, they have recently been shown to have a clinical/therapeutic potential particularly for their immunomodulatory properties. Indeed recent studies suggested a potential application of MSCs for the treatment of experimental autoimmune disorders. It was demonstrated that their effects are in part mediated by the release of soluble factors or extracellular vesicles, including exosomes and microvesicles, stimulating or inhibiting target cells. This review will describe the secretome of MSCs, pointing the attention on the components relevant for their immunodulatory activities.
Export Options
About this article
Cite this article as:
Fierabracci Alessandra, Fattore Del Andrea and Muraca Maurizio, The Immunoregulatory Activity of Mesenchymal Stem Cells: ‘State of Art’ and ‘Future Avenues’, Current Medicinal Chemistry 2016; 23 (27) . https://dx.doi.org/10.2174/0929867323666160627112827
DOI https://dx.doi.org/10.2174/0929867323666160627112827 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible Diabetes (ATTEMPT): A Prospective-Randomized Study in Middle Aged Men and Women
Current Vascular Pharmacology Aspartic Proteases of Human Pathogenic Fungi are Prospective Targets for the Generation of Novel and Effective Antifungal Inhibitors
Current Enzyme Inhibition Disease-Induced Neuroinflammation and Depression
CNS & Neurological Disorders - Drug Targets MicroRNAs as Early Biomarkers in Obesity and Related Metabolic and Cardiovascular Diseases
Current Pharmaceutical Design Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-pancreatic Diseases
Current Stem Cell Research & Therapy Putative Involvement of Endocrine Disruptors in the Alzheimer's Disease Via the Insulin-Regulated Aminopeptidase/GLUT4 Pathway
Current Neuropharmacology Use and Safety of Calcium Channel Blockers in Obstetrics
Current Medicinal Chemistry Homocysteine, Intracellular Signaling and Thrombotic Disorders
Current Medicinal Chemistry Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice
Current Pharmaceutical Design The Spatial QRS-T Angle: Implications in Clinical Practice
Current Cardiology Reviews Role of Vitamin D in Vascular Complications and Vascular Access Outcome in Patients with Chronic Kidney Disease
Current Medicinal Chemistry Recent Advances in Synthetic Chemistry of Diabetic Research
Mini-Reviews in Medicinal Chemistry Pragmatic Analysis of Dyslipidemia Involvement in Coronary Artery Disease: A Narrative Review
Current Cardiology Reviews Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Current Pharmaceutical Design Mitochondrial Alterations and Neuropsychiatric Disorders
Current Medicinal Chemistry Anti-Vascular Endothelial Growth Factor Drug Treatment of Diabetic Macular Edema: The Evolution Continues
Current Diabetes Reviews The Forward Path for Biopharmaceuticals and Biosimilars: Emerging Options in the Selection of Host Cell Systems
Current Biotechnology Methicillin-Resistant <i>Staphylococcus aureus</i>: Treatment with Cultures of Non Drug-Resistant <i>Staphylococcus epidermidis</i>
Recent Patents on Anti-Infective Drug Discovery Obesity Related Kidney Disease
Current Diabetes Reviews Subject Index To Volume 6
Central Nervous System Agents in Medicinal Chemistry