Abstract
Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of biogenic amines can induce adverse reactions and are harmful to animal's health. Therefore, it is crucial to have a clear understanding of how different biogenic amines interact with a body's intestinal function signaling pathways and to monitor the content of biogenic amines in the gastrointestinal tract. And in turn, the proper concentration of dietary protein and balanced amino acids for humans and livestock could be given. Though numerous methods have been developed and improved for the detection of biogenic amines in foods or wines much less attention has been paid directly to the determination of amine levels in the gastrointestinal tract. In this article, we mainly focus on the interaction of amines with the intestinal function signaling pathway and the broad impacts on animal physiology, and our modified method to accurately and quickly detect the biogenic amines in the digesta of an animal intestine.
Keywords: Biogenic amines, gastrointestinal tract, modulation, signaling pathway, HPLC.
Current Protein & Peptide Science
Title:Roles of Biogenic Amines in Intestinal Signaling
Volume: 18 Issue: 6
Author(s): Peixin Fan, Peixia Song, Linsen Li, Chang Huang, Jingshu Chen, Wenjun Yang, Shiyan Qiao, Guoyao Wu, Guolong Zhang*Xi Ma*
Affiliation:
- Department of Animal Science, Oklahoma State University, Stillwater, Oklahoma 74078,United States
- State Key Lab of Animal Nutrition, China Agricultural University, Beijing, 100193,China
Keywords: Biogenic amines, gastrointestinal tract, modulation, signaling pathway, HPLC.
Abstract: Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of biogenic amines can induce adverse reactions and are harmful to animal's health. Therefore, it is crucial to have a clear understanding of how different biogenic amines interact with a body's intestinal function signaling pathways and to monitor the content of biogenic amines in the gastrointestinal tract. And in turn, the proper concentration of dietary protein and balanced amino acids for humans and livestock could be given. Though numerous methods have been developed and improved for the detection of biogenic amines in foods or wines much less attention has been paid directly to the determination of amine levels in the gastrointestinal tract. In this article, we mainly focus on the interaction of amines with the intestinal function signaling pathway and the broad impacts on animal physiology, and our modified method to accurately and quickly detect the biogenic amines in the digesta of an animal intestine.
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Cite this article as:
Fan Peixin, Song Peixia, Li Linsen, Huang Chang, Chen Jingshu, Yang Wenjun, Qiao Shiyan, Wu Guoyao, Zhang Guolong*, Ma Xi*, Roles of Biogenic Amines in Intestinal Signaling, Current Protein & Peptide Science 2017; 18 (6) . https://dx.doi.org/10.2174/1389203717666160627073048
DOI https://dx.doi.org/10.2174/1389203717666160627073048 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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