摘要
糖尿病患者的皮肤和角膜伤口是一个重要的医疗负担。微小核糖核酸是小的非编码核糖核酸,在转录后水平调控蛋白基因的表达。研究发现微小核糖核酸参与创面愈合的各个阶段。微小核糖核酸失调可导致受损或糖尿病患者皮肤和角膜伤口愈合延迟。在这里,我们提出了一个涉及糖尿病皮肤和角膜伤口愈合的微小核糖核酸的文献以及那些作为糖尿病伤口愈合的潜在生物标志物的综合概述。
关键词: 微小核糖核酸,伤口愈合,皮肤,角膜,糖尿病的发病机制。
Current Molecular Medicine
Title:Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing
Volume: 16 Issue: 6
Author(s): F. Fahs, X.-L. Bi, F.-S. Yu, L. Zhou, Q.-S. Mi
Affiliation:
关键词: 微小核糖核酸,伤口愈合,皮肤,角膜,糖尿病的发病机制。
摘要: Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of proteincoding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing.
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Cite this article as:
F. Fahs, X.-L. Bi, F.-S. Yu, L. Zhou, Q.-S. Mi , Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing, Current Molecular Medicine 2016; 16 (6) . https://dx.doi.org/10.2174/1566524016666160607091156
DOI https://dx.doi.org/10.2174/1566524016666160607091156 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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