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Current Neuropharmacology



ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions

Author(s): Miriam Goebel-Stengel and Andreas Stengel

Volume 14 , Issue 8 , 2016

Page: [882 - 891] Pages: 10

DOI: 10.2174/1570159X14666160601153202

Price: $65


Background: Nucleobindin2 (NUCB2)/nesfatin-1 plays a well-established role in homeostatic functions associated with food intake and stress integration.

Aim: This review focusses on NUCB2/nesfatin-1’s central effects on gastrointestinal functions and will summarize the effects on food intake, motility and secretion with focus on the upper gastrointestinal tract.

Results: We will highlight the stressors that influence brain NUCB2/nesfatin-1 expression and discuss functional implications. In addition to traditional acute psychological and physical stressors such as restraint stress and abdominal surgery we will look at immunological, visceral and metabolic stressors as well as a chronic combination stress model that have been shown to affect NUCB2/nesfatin-1 signaling and describe associated functional consequences.

Keywords: Brain-gut axis, corticotropin releasing factor, CRF, food intake, motility, secretion.

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