摘要
传统上,心脏被认为是一种终末分化的器官。然而,本世纪初的有丝分裂活性的增加在缺血性心肌病、扩张型心肌病中均有报道,与健康对照组相比,强调潜在损伤后的再生。由于在骨髓和他们所谓的能力分化成其他细胞系的成体干细胞的存在,这些为心肌再生的快速细胞群估计是最适合的备选物。自体骨髓单个核细胞的临床试验中,在左室射血分数中,使用冠脉内或直接心肌内注射的方法始终显示只有轻微的改善。这可以由有限的心肌分化潜能来做解释。为了获得更令人信服的改善心功能的数据,在真正的心肌再生的基础上,研究的重点已转向居民心脏祖细胞。几种提取方法已被描述:c-kit的表面标志是首先被使用,但实验研究证明c-kit+细胞只有轻微有助于再生心肌梗死后。球的形成被用于分离细胞所谓的cardiosphere(CDC),并且该细胞向心肌细胞分化是一件罕见的事件。最近一种新的基于酶乙醛脱氢酶(ALDH)来源于心房组织(心脏房干细胞–CASCS)的细胞的存在已经被确定了。这些细胞显著改善了区域和全球的LV射血分数,是基于大量的植入和一致的分化为成熟的心肌细胞中的(98%)部分。
关键词: 心脏干细胞;分化;磁共振成像;映射;迁移;骨髓间充质干细胞;心肌梗死;血小板衍生生长因子。
Current Medicinal Chemistry
Title:From Bone Marrow to Cardiac Atrial Appendage Stem Cells for Cardiac Repair: A Review
Volume: 23 Issue: 23
Author(s): Marc Hendrikx, Yanick Fanton, Leen Willems, Annick Daniels, Jeroen Declercq, Severina Windmolders, Karen Hensen, Remco Koninckx, Luc Jamaer, Jasperina Dubois, Dagmara Dilling-Boer, Jos Vandekerkhof, Filip Hendrikx, Eric Bijnens, Nick Heuts and Boris Robic, Virginie Bito, Marcel Ameloot, Paul Steels, Jean-Luc Rummens
Affiliation:
关键词: 心脏干细胞;分化;磁共振成像;映射;迁移;骨髓间充质干细胞;心肌梗死;血小板衍生生长因子。
摘要: Traditionally the heart is considered a terminally differentiated organ. However, at the beginning of this century increased mitotic activity was reported in ischemic and idiopathic dilated cardiomyopathy hearts, compared to healthy controls, underscoring the potential of regeneration after injury. Due to the presence of adult stem cells in bone marrow and their purported ability to differentiate into other cell lineages, this cell population was soon estimated to be the most suited candidate for cardiac regeneration. Clinical trials with autologous bone marrow-derived mononuclear cells, using either an intracoronary or direct intramyocardial injection approach consistently showed only minor improvement in global left ventricular ejection fraction. This was explained by their limited cardiomyogenic differentiation potential. To obtain more convincing improvement in cardiac function, based on true myocardial regeneration, the focus of research has shifted towards resident cardiac progenitor cells. Several isolation procedures have been described: the c-kit surface marker was the first to be used, however experimental research has clearly shown that c-kit+ cells only marginally contribute to regeneration post myocardial infarction. Sphere formation was used to isolate the so-called cardiosphere derived cells (CDC), and also in this cell population cardiomyogenic differentiation is a rare event. Recently a new type of stem cells derived from atrial tissue (cardiac atrial stem cells – CASCs) was identified, based on the presence of the enzyme aldehyde dehydrogenase (ALDH). Those cells significantly improve both regional and global LV ejection fraction, based on substantial engraftment and consistent differentiation into mature cardiomyocytes (98%).
Export Options
About this article
Cite this article as:
Marc Hendrikx, Yanick Fanton, Leen Willems, Annick Daniels, Jeroen Declercq, Severina Windmolders, Karen Hensen , Remco Koninckx, Luc Jamaer, Jasperina Dubois, Dagmara Dilling-Boer, Jos Vandekerkhof, Filip Hendrikx, Eric Bijnens, Nick Heuts and Boris Robic, Virginie Bito, Marcel Ameloot, Paul Steels, Jean-Luc Rummens , From Bone Marrow to Cardiac Atrial Appendage Stem Cells for Cardiac Repair: A Review, Current Medicinal Chemistry 2016; 23 (23) . https://dx.doi.org/10.2174/0929867323666160525114735
DOI https://dx.doi.org/10.2174/0929867323666160525114735 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration
Current Topics in Medicinal Chemistry Comparison of High-Sensitive CRP, RDW, PLR and NLR between Patients with Chronic Obstructive Pulmonary Disease and Chronic Heart Failure
Current Respiratory Medicine Reviews Editorial [Hot Topic: Modifying Cardiovascular Risk Factors: Epidemiology and Characteristics of Hypertension-Related Disorders (Executive Guest Editor: Aurelio Leone)]
Current Pharmaceutical Design Susceptibility Genes in Hypertension
Current Pharmaceutical Design Interatrial Block in the Modern Era
Current Cardiology Reviews Novel Strategies for the Management of Acute Decompensated Heart Failure
Current Cardiology Reviews Gene Transfer for Inherited Metabolic Disorders of the Liver: Immunological Challenges
Current Pharmaceutical Design Smoking and Hypertension: Effects on Clinical, Biochemical and Pathological Variables Due to Isolated or Combined Action on Cardiovascular System
Current Pharmaceutical Design Bayes Syndrome and Imaging Techniques
Current Cardiology Reviews Heme Oxygenase-1 in Tumor Biology and Therapy
Current Drug Targets MicroRNAs in Atrial Fibrillation
Current Medicinal Chemistry Micro-RNA in Disease and Gene Therapy
Current Drug Discovery Technologies Regulatory Mechanisms of Calcineurin Phosphatase Activity
Current Medicinal Chemistry Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance
Current Cardiology Reviews Modulation of Rack-1/PKCβII Signalling By Soluble AβPPα in SH-SY5Y Cells
Current Alzheimer Research Myocardial Perfusion and Coronary Vasomotor Function: Emerging Role of PET Imaging
Vascular Disease Prevention (Discontinued) The Heart Metabolism: Pathophysiological Aspects in Ischaemia and Heart Failure
Current Pharmaceutical Design Potential Targets for Intervention in Radiation-Induced Heart Disease
Current Drug Targets Functional Variants of the Interleukin-23 Receptor Gene in Non-Gastrointestinal Autoimmune Diseases
Current Medicinal Chemistry Measurement of the Endogenous Adenosine Concentration in Humans In Vivo: Methodological Considerations
Current Drug Metabolism