Founded in 2006, Crown Bioscience is a premier drug discovery company providing cutting-edge translational platforms and world class drug discovery solutions for its biotech and pharmaceutical partners in dedicated therapeutic areas of oncology and metabolic diseases. With the successful development of the business, an innovation system has been built by the entrepreneur community of Crown Bioscience. This community includes all the founders and some top managers in Crown Bioscience. They have successively established a series of start-ups extending the venture territory of their parent company. All these firms constitute an open innovation system. Based on the case study of Crown Bioscience, we found that: (1) The core of the founding team, Dr. Alex Yue Wu, plays a critical role in the emerging of the entrepreneur community. His open all-win mind guarantees the prosperity of this community. (2) One parent start-up, dominating a right position in the industry value chain, can cultivate rich opportunities for the community. (3) Knowledge sharing and learning by entrepreneurship in the community are drivers for dynamic capability building.