Synthetic Strategies for Lysine-Proline Chimeras: An Overview

Letizia      Giampietro; Rosa      Amoroso; Marco      Chiarini

Abstract

Proline-amino acid chimeras are conformationally rigid amino acid analogues, important in understanding the spatial requirements for receptor affinity and biological activity of natural amino acids and peptides. In medicinal chemistry, a great variety of lysine-proline chimeras was considered in light of the importance of their biological roles. In this review, we analyze the most relevant synthetic approaches to obtain lysine-proline chimeras.

Keywords: Proline, Lysine, amino acid, synthesis, chimera, synthetic approaches.

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Current Bioactive Compounds

Title:Synthetic Strategies for Lysine-Proline Chimeras: An Overview

Volume: 12 Issue: 3

Author(s): Letizia Giampietro, Rosa Amoroso and Marco Chiarini

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Keywords: Proline, Lysine, amino acid, synthesis, chimera, synthetic approaches.

Abstract: Proline-amino acid chimeras are conformationally rigid amino acid analogues, important in understanding the spatial requirements for receptor affinity and biological activity of natural amino acids and peptides. In medicinal chemistry, a great variety of lysine-proline chimeras was considered in light of the importance of their biological roles. In this review, we analyze the most relevant synthetic approaches to obtain lysine-proline chimeras.

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Giampietro Letizia, Amoroso Rosa and Chiarini Marco, Synthetic Strategies for Lysine-Proline Chimeras: An Overview, Current Bioactive Compounds 2016; 12 (3) . https://dx.doi.org/10.2174/1573407212666160511162405

DOI https://dx.doi.org/10.2174/1573407212666160511162405	Print ISSN 1573-4072
Publisher Name Bentham Science Publisher	Online ISSN 1875-6646