摘要
挥发性有机化合物(VOCs)为健康和患病的人类成长的生化过程提供了独特的视野。然而,他们的诊断使用被有限的生化或细胞的起源以及其与某些疾病的频繁使用所阻断了。预期的主要进步从人类的原代细胞分析,细胞系到培养的微生物。在这篇综述中,数据库中的125例可靠地确定了以前报道的人类健康和患病的细胞,组合了挥发性有机化合物,并对他们的潜在来源进行了讨论。它们中的大多数也在其他的研究矩阵(呼吸、尿液、唾液、粪便、血液、皮肤放射)中被发现。此外,基于ISO-11843指南的基础上,持续改进定性和定量的分析方法,暗示了标准化分析过程和更具可比性结果的必要性。这些提供的数据有助于获得一个更为完整的人类volatilome并为未来潜在的挥发性生物标志物提供可靠性。
关键词: 生物标志物;呼吸分析;癌症;GC-MS;人类细胞系;标准化;挥发性有机化合物(VOCs),volatilome。
Current Medicinal Chemistry
Title:A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines
Volume: 23 Issue: 20
Author(s): Wojciech Filipiak, Pawel Mochalski, Anna Filipiak, Clemens Ager, Raquel Cumeras, Cristina E. Davis, Agapios Agapiou and Karl Unterkofler, Jakob Troppmair
Affiliation:
关键词: 生物标志物;呼吸分析;癌症;GC-MS;人类细胞系;标准化;挥发性有机化合物(VOCs),volatilome。
摘要: Volatile organic compounds (VOCs) offer unique insights into ongoing biochemical processes in healthy and diseased humans. Yet, their diagnostic use is hampered by the limited understanding of their biochemical or cellular origin and their frequently unclear link to the underlying diseases. Major advancements are expected from the analyses of human primary cells, cell lines and cultures of microorganisms. In this review, a database of 125 reliably identified VOCs previously reported for human healthy and diseased cells was assembled and their potential origin is discussed. The majority of them have also been observed in studies with other human matrices (breath, urine, saliva, feces, blood, skin emanations). Moreover, continuing improvements of qualitative and quantitative analyses, based on the recommendations of the ISO-11843 guidelines, are suggested for the necessary standardization of analytical procedures and better comparability of results. The data provided contribute to arriving at a more complete human volatilome and suggest potential volatile biomarkers for future validation.
Dedication:This review is dedicated to the memory of Prof. Dr. Anton Amann, who sadly passed away on January 6, 2015. He was motivator and motor for the field of breath research.
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Wojciech Filipiak, Pawel Mochalski, Anna Filipiak, Clemens Ager, Raquel Cumeras, Cristina E. Davis, Agapios Agapiou and Karl Unterkofler, Jakob Troppmair , A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines, Current Medicinal Chemistry 2016; 23 (20) . https://dx.doi.org/10.2174/0929867323666160510122913
DOI https://dx.doi.org/10.2174/0929867323666160510122913 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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