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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Desirable Properties for 3rd Generation Cyclooxygenase-2 Inhibitors

Author(s): Micky D. Tortorella, Yanmei Zhang and John Talley

Volume 16 , Issue 16 , 2016

Page: [1284 - 1289] Pages: 6

DOI: 10.2174/1389557515666160509125702

Price: $65

Abstract

Coxibs are a class of powerful drugs used by millions of people worldwide to treat a wide variety of ailments such as muscular skeletal pain and inflammation. The primary mechanism of action of coxibs is the potent inhibition of the COX-2 enzyme. Unfortunately, their use is limited to patients due to a variety of factors including poor solubility, negative effects on renal clearance and increased risk of cardiovascular pathology. However, because of their effectiveness in blocking PGE2 mediated inflammation, a key pathway that drives many diseases, there is a clear unmet medical need to develop new COX-2 inhibitors that are free of the aforementioned problems. The purpose of this prospectus is to define the specific properties that are desired in 3rd generation coxibs as a starting point for the development of new and better drugs.

Keywords: COX-2, Inflammation, PGE2, Cancer, Pain.


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