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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Serum miRNAs Signature Plays an Important Role in Keloid Disease

Author(s): Y. Luan, Y. Liu, C. Liu, Q. Lin, F. He, X. Dong and Z. Xiao

Volume 16, Issue 5, 2016

Page: [504 - 514] Pages: 11

DOI: 10.2174/1566524016666160429121345

open access plus


The molecular mechanism underlying the pathogenesis of keloid is largely unknown. MicroRNA (miRNA) is a class of small regulatory RNA that has emerged as a group of posttranscriptional gene repressors, participating in diverse pathophysiological processes of skin diseases. We investigated the expression profiles of miRNAs in the sera of patients to decipher the complicated factors involved in the development of keloid disease. MiRNA expression profiling in the sera from 9 keloid patients and 7 normal controls were characterized using a miRNA microarray containing established human mature and precursor miRNA sequences. Quantitative real-time PCR was performed to confirm the expression of miRNAs. The putative targets of differentially expressed miRNAs were functionally annotated by bioinformatics. MiRNA microarray analysis identified 37 differentially expressed miRNAs (17 upregulated and 20 downregulated) in keloid patients, compared to the healthy controls. Functional annotations revealed that the targets of those differentially expressed miRNAs were enriched in signaling pathways essential for scar formation and wound healing. The expression profiling of miRNAs is altered in the keloid, providing a clue for the molecular mechanisms underlying its initiation and progression. MiRNAs may partly contribute to the etiology of keloids by affecting the critical signaling pathways relevant to keloid pathogenesis.

Keywords: Keloid, microRNA, serum, pathogenesis, scar, etiology.

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