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Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

Synthetic Lethal Interactions in Cancer Therapy

Author(s): Xinwei Geng, Xiaohui Wang, Dan Zhu* and Songmin Ying*

Volume 17, Issue 4, 2017

Page: [304 - 310] Pages: 7

DOI: 10.2174/1568009616666160426122736

Price: $65

Abstract

Background: Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as “synthetic lethality”. Nowadays, synthetic lethality has become a widely used anti-cancer strategy.

Method: We reviewed the synthetic lethal interactions exploited in anticancer therapies before 2016.

Conclusion: Synthetic lethality is a well proved anticancer strategy and more synthetic lethal interactions is being translated into clinical cancer therapies.

Keywords: Synthetic lethality, targeted therapy, PARP inhibitors, drug resistance, cancer therapy, signaling pathways.

Graphical Abstract

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