Synthetic Lethal Interactions in Cancer Therapy

Title:Synthetic Lethal Interactions in Cancer Therapy

Volume: 17 Issue: 4

Author(s): Xinwei Geng, Xiaohui Wang, Dan Zhu*Songmin Ying*

Affiliation:

• Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua,China

• Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou,China

Keywords: Synthetic lethality, targeted therapy, PARP inhibitors, drug resistance, cancer therapy, signaling pathways.

Abstract: Background: Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as “synthetic lethality”. Nowadays, synthetic lethality has become a widely used anti-cancer strategy.

Cite this article as:

Geng Xinwei, Wang Xiaohui, Zhu Dan*, Ying Songmin*, Synthetic Lethal Interactions in Cancer Therapy, Current Cancer Drug Targets 2017; 17(4) . https://dx.doi.org/10.2174/1568009616666160426122736