Generic placeholder image

Recent Patents on Nanotechnology


ISSN (Print): 1872-2105
ISSN (Online): 2212-4020

Review Article

The Use of Inorganic Compounds in Photodynamic Therapy: Improvements in Methods and Photosensitizer Design

Author(s): Shivani Boodram, Jimmie L. Bullock, Varma H. Rambaran and Alvin A. Holder

Volume 11, Issue 1, 2017

Page: [3 - 14] Pages: 12

DOI: 10.2174/1872210510666160425121512

Price: $65


Background: Nanotechnology has provided significant benefits to photodynamic therapy (PDT), which has revolutionized treatments of several diseases. The success of this versatile technique is governed by the sequential in situ generation of reactive oxygen species, after a suitable photosensitizer has been irradiated by a defined wavelength of light. While PDT provides a minimally-invasive and convenient method for the treatment of several afflictions, the efficiency of this therapeutic strategy still has potential for improvements. Several bodies of works within this realm have highlighted the use of inorganic compounds, which is pivotal for the development of photosensitizers (PSs), nanoparticles (NPs) and irradiation sources.

Methods: The past decade of online patented reports based on PDT were reviewed.

Results: The patented reports analyzed showcased the integration of nanomaterials and inorganic compounds into PDT. The patents were grouped according to the following categories, viz., “Nanoparticles in Photodynamic Therapy”, “Photosensitizers Incorporating Various Metal Centers”, and “Modifications to Light Delivery”.

Conclusion: PDT is a suitable treatment option for several diseases however there are several challenges and limitations. The incorporation of NPs in the field of PDT is an extremely promising avenue which can be utilized to improve the execution of PDT. Furthermore, the use of inorganic compounds was noted to be frequented in the development of PSs and NP conjugates. The patents presented addressed the associated problems with PDT but there still remains an opportunity for continued research efforts so that more clinical applications are possible.

Keywords: Anti-microbial therapy, cancer treatment, lanthanides, nanoparticles, ocular diseases, photodynamic therapy, photosensitizers, transition metals.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy