Abstract
The effects of non-thermal intensity of microwave (NT MW)- treated physiological solutions (PS) on muscle contractility, 45Ca uptake by muscle and muscle hydration of snail isolated heart in normal and K+-free PS were studied. The intra-cordial perfusion by NT MW-treated PS led to inhibition of heart beating with gradual decrease of the amplitudes of muscle contraction, the weakness of the Na+/K+ pump-induced transient inhibition of heart beating (TIHB), the inhibition of 45Ca2+ uptake by muscle, the increase of intracellular cGMP contents and muscle dehydration. The obtained data serve as additional evidence for hypothesis that cell bathing aqua solution is a primary target for non-thermal effect of MW on cells and organisms.
Keywords: Non-thermal, MW, Heart muscle, Intracellular Ca2+, cGMP, Muscle hydration.
Current Chemical Biology
Title:The Effect of Non-Thermal Microwave-Treated Physiological Solution on Isolated Heart Muscle of Snail
Volume: 10 Issue: 1
Author(s): Gayane Ayrapetyan, Hovik Hayrapetyan and Sinerik Ayrapetyan
Affiliation:
Keywords: Non-thermal, MW, Heart muscle, Intracellular Ca2+, cGMP, Muscle hydration.
Abstract: The effects of non-thermal intensity of microwave (NT MW)- treated physiological solutions (PS) on muscle contractility, 45Ca uptake by muscle and muscle hydration of snail isolated heart in normal and K+-free PS were studied. The intra-cordial perfusion by NT MW-treated PS led to inhibition of heart beating with gradual decrease of the amplitudes of muscle contraction, the weakness of the Na+/K+ pump-induced transient inhibition of heart beating (TIHB), the inhibition of 45Ca2+ uptake by muscle, the increase of intracellular cGMP contents and muscle dehydration. The obtained data serve as additional evidence for hypothesis that cell bathing aqua solution is a primary target for non-thermal effect of MW on cells and organisms.
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Cite this article as:
Ayrapetyan Gayane, Hayrapetyan Hovik and Ayrapetyan Sinerik, The Effect of Non-Thermal Microwave-Treated Physiological Solution on Isolated Heart Muscle of Snail, Current Chemical Biology 2016; 10 (1) . https://dx.doi.org/10.2174/2212796810666160419152816
DOI https://dx.doi.org/10.2174/2212796810666160419152816 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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