Abstract
Among gastro-intestinal cancers, pancreatic cancer is the fourth leading cause of cancer-related death mainly due to late diagnosis. Although there is significant improvement in chemotherapy regimen but still five year survival rate is maximum 6%. Resistance offered by cancer stem cells towards the chemotherapeutic drug might be one solid reason behind this. Cancer stem cells (CSC), a subset of the heterogeneous cell population of a tumor are self-renewable and can differentiate into all types of cancer cells. Inhibition of CSC activity might be a good approach in treatment of cancer. Anti-cancer activities of several naturally occurring phytochemicals are well established. Plethora of evidences supports the protective role of phytochemicals in suppressing CSC acivity. Here in this review an attempt has been made to summarize the activity of phytochemicals like curcumin, resveratrol, quercetin, catechin etc. towards inhibiting CSCs in pancreatic cancer.
Keywords: Stem cell, pancreatic cancer, resistance, phytochemicals, curcumin, resveratrol, quercetin.
Current Chemical Biology
Title:Phytochemicals and Cancer Stem Cells: A Pancreatic Cancer Overview
Volume: 10 Issue: 2
Author(s): Suvroma Gupta and Dipankar Pramanik
Affiliation:
Keywords: Stem cell, pancreatic cancer, resistance, phytochemicals, curcumin, resveratrol, quercetin.
Abstract: Among gastro-intestinal cancers, pancreatic cancer is the fourth leading cause of cancer-related death mainly due to late diagnosis. Although there is significant improvement in chemotherapy regimen but still five year survival rate is maximum 6%. Resistance offered by cancer stem cells towards the chemotherapeutic drug might be one solid reason behind this. Cancer stem cells (CSC), a subset of the heterogeneous cell population of a tumor are self-renewable and can differentiate into all types of cancer cells. Inhibition of CSC activity might be a good approach in treatment of cancer. Anti-cancer activities of several naturally occurring phytochemicals are well established. Plethora of evidences supports the protective role of phytochemicals in suppressing CSC acivity. Here in this review an attempt has been made to summarize the activity of phytochemicals like curcumin, resveratrol, quercetin, catechin etc. towards inhibiting CSCs in pancreatic cancer.
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Cite this article as:
Gupta Suvroma and Pramanik Dipankar, Phytochemicals and Cancer Stem Cells: A Pancreatic Cancer Overview, Current Chemical Biology 2016; 10(2) . https://dx.doi.org/10.2174/2212796810666160419152309
DOI https://dx.doi.org/10.2174/2212796810666160419152309 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |

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