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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Onychomycosis and its Chemotherapy

Author(s): Anwer Basha, Fatima Basha, Syed K. Ali, Paul R. Hanson, Berl R. Oakley, Heather Hajovsky and Lester A. Mitscher

Volume 23 , Issue 16 , 2016

Page: [1609 - 1624] Pages: 16

DOI: 10.2174/0929867323666160411130103

Price: $65


Onychomycosis (fungal nail infections) is very common worldwide but is fortunately not often lethal. Several powerful drugs have been introduced into clinical practice in recent years, but these infections remain difficult to cure primarily due to the difficulty of penetration of drug to the site of the infection in therapeutic concentrations. The nature of the disease, the causative fungi, and the characteristics of the drugs employed to treat this condition are discussed in this review.

Keywords: Antifungal drugs, onychomycosis, dermatophytes, griseofulvin, azoles, polyene macrolides, allyl amines, ciclopirox, tavaborole, tea tree oil.

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