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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome

Author(s): Hitender Sharma and Sunil Kumar*

Volume 24 , Issue 10 , 2017

Page: [1007 - 1047] Pages: 41

DOI: 10.2174/0929867323666160406120814

Price: $65

Abstract

This review covers recent discoveries of phytoconstituents, herbal extracts and some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as one of their mechanisms of action. Recent researches have demonstrated AMPK activation to ameliorate multiple components of metabolic syndrome by regulating a balance between anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation by natural agents from the perspective of its functional consequences on enzymes, transcription factors and signaling molecules and also on other potential factors contributing in the amelioration of metabolic syndrome.

Keywords: Cardiovascular disorders, diabetes, obesity, metabolic syndrome, transcription factors, phytoconstituents.


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