Review Article

The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases

Author(s): Aleksandra Piechota-Polanczyk and Alicja Jozkowicz

Volume 18, Issue 6, 2017

Page: [674 - 686] Pages: 13

DOI: 10.2174/1389450117666160401123600

Price: $65

Abstract

Cardiovascular diseases (CVD) are associated with the dysfunction of endothelium that regulates the contractile state of vascular walls and cellular composition. Recent large clinical trials indicated that lipid-modifying interventions decrease the risk of CVD in patients with hypercholesterolemia and in those with relatively normal levels of LDL cholesterol. They also highlighted lipid-independent role of well-established lipid-lowering drugs- statins- which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and are used in the treatment of hypercholesterolemia and reduction of atherosclerosis. Novel therapeutic approaches of statins include their influence on heme oxygenase 1 (HO-1) and HO-1 related signaling pathways such as activator protein (AP)-1, protein kinase G (PKG), extracellular matrix-regulated kinase (ERK), p38 MAPK or NFκB in vascular wall cells. This review aimed to describe the molecular mechanisms involved in the induction of HO-1 under different statins in the most common CVD.

Keywords: Abdominal aortic aneurysm, antioxidants, atherosclerosis, cardiac diseases, cardiovascular diseases, heme oxygenase- 1, oxidative stress, statins.

Graphical Abstract

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