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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

The Emerging Role of Bradykinin in the Pathogenesis of Osteoarthritis and its Possible Clinical Implications

Author(s): Sara Tenti, Nicola Antonio Pascarelli, Sara Cheleschi, Giacomo Maria Guidelli and Antonella Fioravanti

Volume 12 , Issue 3 , 2016

Page: [177 - 184] Pages: 8

DOI: 10.2174/1573397112666160331143305

Price: $65


Osteoarthritis (OA) is a multifaceted disorder defined by the alteration of homeostasis and degradation in articular cartilage. Recently mounting evidence suggests that OA should be conceived as an inflammatory disease rather than a simple wear-and-tear problem. Bradykinin (BK) and B2 receptors play a role in the pathogenesis of OA. The aim of this paper is to analyze preclinical and clinical studies examining the potential role of BK and of B2 receptor blockade in OA pathogenesis. We analyzed the data about the effects of BK in synoviocytes, endothelial cells and chondrocytes cultures and described the action of B2 receptor antagonists (Icatibant and Fasitibant). In conclusion, the BK is an endogenous proinflammatory molecule that is involved in the pathophysiology of OA, and B2 receptor antagonists are believed to be considered as a potential symptomatic therapy for this disease. There is a need for further preclinical and clinical trials to better explain the mechanisms of action and the efficacy and tolerability of the B2 receptor antagonists in OA.

Keywords: Bradykinin B2 Receptor antagonists, Bradykinin, Osteoarthritis, OA, Chondrocytes, Endothelial cells, Synoviocytes, Synovial fluid.

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