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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

The Chemistry of Galanthamine. Classical Synthetic Methods and Comprehensive Study on its Analogues

Author(s): Péter Keglevich, Csaba Szántay and László Hazai

Volume 16, Issue 18, 2016

Page: [1450 - 1461] Pages: 12

DOI: 10.2174/1389557516666160321114556

open access plus


Galanthamine as an Amaryllidaceae alkaloid has an important role in the treatment of Alzheimer’s disease. Some efforts were made to elaborate the total synthesis, and hundreds of its derivatives were prepared to find a more effective molecule with advantageous properties. Moreover, almost every part of the tetracycle was changed; in members of the rings, in the nature and position of the heteroatoms, and ring-opened analogues were also synthesized. In this review the basic synthetic works and the most important derivatives and analogues are overviewed.

Keywords: Acetylcholinesterase inhibition, Alzheimer's disease, butyrylcholinesterase inhibitor, galanthamine, hexahydrobenzofurobenzazepine, structural analogues.

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