Abstract
Background: Apitherapeutic products contain many valuable bioactive compounds which are responsible for biologically active features such as anti-oxidant, anti-viral, anti-microbial and anti-inflammatory properties.
Objective: This study investigated in vitro anti-inflammatory potentials in terms of hyaluronidase inhibition of three different bee products, propolis, pollens and royal jellies.
Methods: Water soluble extracts of the samples were prepared, and inhibitions of bovine serum hyaluronidase were used. Inhibitions were expressed as percentages of inhibition (IC50;g/mL or mg/mL) causing 50% inhibition of the enzyme.
Results: All the bee products exhibited anti-hyaluronidase activities in the order propolis, pollen, and finally royal jelly. Inhibition was also correlated with the samples’ total phenolic contents.
Conclusion: The study results confirm that water-soluble propolis is the best inhibitory agent among the bee products, and that these may be used as anti-inflammatory agents. However, further in vivo studies are now needed to clarify their pharmaceutical potentials as medicines.
Keywords: Anti-inflammatory, hyaluronidase, propolis, pollen, royal jelly, phenolics.
Graphical Abstract
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