Abstract
Quinone bioreductive prodrugs were developed to target the hypoxic or the reductase- rich population of solid tumours. The mechanism of their selective activation is based on their ability to convert the quinone sub-structure to their activated semiquinone or hydroquinone species affording the active species. Recent studies on their biochemical activation process have resulted in their development as delivery agents that can effectively release a potent (but not necessarily a cytotoxic) agent under hypoxic / reductive conditions. This technology platform is currently being used to design / identify, and synthesise novel quinone bioreductive delivery agents to target cancer and other diseses where hypoxia and / or reductive enzymes play a major pathophysiological role.
Keywords: quinone, indolequinone, benzoquinone, naphthoquinone, bioreductive agents, hypoxia-selectivity, delivery agents, oxidoreductive enzymes
Current Drug Delivery
Title: Quinone Bioreductive Prodrugs as Delivery Agents
Volume: 1 Issue: 4
Author(s): Mohammed Jaffar, Nathalie Abou-Zeid, Li Bai, Ibrahim Mrema, Ian Robinson, Richard Tanner and Ian J. Stratford
Affiliation:
Keywords: quinone, indolequinone, benzoquinone, naphthoquinone, bioreductive agents, hypoxia-selectivity, delivery agents, oxidoreductive enzymes
Abstract: Quinone bioreductive prodrugs were developed to target the hypoxic or the reductase- rich population of solid tumours. The mechanism of their selective activation is based on their ability to convert the quinone sub-structure to their activated semiquinone or hydroquinone species affording the active species. Recent studies on their biochemical activation process have resulted in their development as delivery agents that can effectively release a potent (but not necessarily a cytotoxic) agent under hypoxic / reductive conditions. This technology platform is currently being used to design / identify, and synthesise novel quinone bioreductive delivery agents to target cancer and other diseses where hypoxia and / or reductive enzymes play a major pathophysiological role.
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Cite this article as:
Jaffar Mohammed, Abou-Zeid Nathalie, Bai Li, Mrema Ibrahim, Robinson Ian, Tanner Richard and Stratford J. Ian, Quinone Bioreductive Prodrugs as Delivery Agents, Current Drug Delivery 2004; 1 (4) . https://dx.doi.org/10.2174/1567201043334560
DOI https://dx.doi.org/10.2174/1567201043334560 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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