Abstract
β-Aminocarbonyl compounds are useful building blocks for the synthesis of biologically and medicinally important molecules. They are important intermediates for molecules like β-amino alcohols, β-amino acids and lactams which have applications in various pharmaceutical and natural product syntheses. The derivatives of β-aminocarbonyl compounds have found applications as diverse therapeutic agents such as antimicrobial, anti-inflammatory, anticonvulsant, anticancer, etc. Due to the wide diversity of applications, the methods for their synthesis are focus of research. In the present review, we have compiled some of the important catalysts and reagents used for the synthesis using Mannich reaction and their potential pharmaceutical applications.
Keywords: β-amino acids, β-Aminocarbonyl compounds, bioactivity, C-C Bond formation, Mannich reaction, multicomponent reaction.
Mini-Reviews in Organic Chemistry
Title:β-Aminocarbonyl Compounds: Chemistry and Biological Activities
Volume: 13 Issue: 2
Author(s): Ram Singh, Geetika Bhasin, Richa Srivastava and Geetanjali
Affiliation:
Keywords: β-amino acids, β-Aminocarbonyl compounds, bioactivity, C-C Bond formation, Mannich reaction, multicomponent reaction.
Abstract: β-Aminocarbonyl compounds are useful building blocks for the synthesis of biologically and medicinally important molecules. They are important intermediates for molecules like β-amino alcohols, β-amino acids and lactams which have applications in various pharmaceutical and natural product syntheses. The derivatives of β-aminocarbonyl compounds have found applications as diverse therapeutic agents such as antimicrobial, anti-inflammatory, anticonvulsant, anticancer, etc. Due to the wide diversity of applications, the methods for their synthesis are focus of research. In the present review, we have compiled some of the important catalysts and reagents used for the synthesis using Mannich reaction and their potential pharmaceutical applications.
Export Options
About this article
Cite this article as:
Singh Ram, Bhasin Geetika, Srivastava Richa and Geetanjali , β-Aminocarbonyl Compounds: Chemistry and Biological Activities, Mini-Reviews in Organic Chemistry 2016; 13 (2) . https://dx.doi.org/10.2174/1570193X13666160225001122
DOI https://dx.doi.org/10.2174/1570193X13666160225001122 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Exploring New Frontiers in Anti-inflammatory Treatment with Small Molecule Compounds
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Patents on Oral Insulin Delivery
Recent Patents on Drug Delivery & Formulation Update on COX-2 Selective Inhibitors: Chemical Classification, Side Effects and their Use in Cancers and Neuronal Diseases
Current Topics in Medicinal Chemistry A Review: The Anti-inflammatory, Anticancer and Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice
Current Medicinal Chemistry The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications
Mini-Reviews in Medicinal Chemistry An Overview of Natural Plant Products in the Treatment of Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: Metabolic Disorders, Drug Development, Drug Design and Biomarkers)
Current Pharmaceutical Design Current Progress of Lipid Analysis in Metabolic Diseases by Mass Spectrometry Methods
Current Medicinal Chemistry Protein/Polyphenol Interactions: Past and Present Contributions. Mechanisms of Astringency Perception
Current Organic Chemistry Perspectives for Novel Mixed Diruthenium-Organic Drugs as Metallopharmaceuticals in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Naringenin and Ellagic Acid Reduce Tetrazolium Salt in the Absence of Cells
The Natural Products Journal Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Medicinal Chemistry Potential Interactions of Carotenoids with Other Bioactive Food Components in the Prevention of Chronic Diseases
Current Bioactive Compounds The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Current Medicinal Chemistry - Anti-Cancer Agents Expression, Distribution and Regulation of Phosphodiesterase 5
Current Pharmaceutical Design Pharmacophore and Binding Analysis of Known and Novel B-RAF Kinase Inhibitors
Current Medicinal Chemistry Treating High Density Lipoprotein Cholesterol (HDL-C): Quantity Versus Quality
Current Pharmaceutical Design The Epithelial-Mesenchymal Transition Pathway in Two Cases with Gastric Metastasis Originating from Breast Carcinoma, One with a Metachronous Primary Gastric Cancer
Recent Patents on Anti-Cancer Drug Discovery Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB
Recent Patents on Inflammation & Allergy Drug Discovery Application of Baculovirus-Insect Cell Expression System for Human Therapy
Current Pharmaceutical Biotechnology Molecular Cloning of a Novel PPEF-1 Gene Variant from a T-Cell Lymphoblastic Lymphoma Cell Line
Recent Patents on DNA & Gene Sequences