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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Porcine Pancreatic Lipase as a Catalyst in Organic Synthesis

Author(s): Nikolay L. Eremeev and Sergey Y. Zaitsev

Volume 13, Issue 1, 2016

Page: [78 - 85] Pages: 8

DOI: 10.2174/1570193X13666160225000520

Price: $65


The article is a mini-review of the porcine pancreatic lipase (PPL) application as a catalyst in organic synthesis. Together with well-known stereo-selective hydrolysis and synthesis there were described examples of new (opened mostly last decade) PPL-catalyzed reactions: Michael and thio- Michael addition, aldol condensation, Henry reaction, Morita-Baylis-Hillman reaction, Knoevenagel condensation, Mannich reaction, one-pot catalysis of some multicomponent reactions, polymerization of different monomers. The study of potential new catalytic capabilities of PPL in organic synthesis permits successfully expand the range of biotechnological applications of this enzyme at both laboratory and industrial levels.

Keywords: Biotechnological applications, organic synthesis, porcine pancreatic lipase.

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