综述：作为阿片肽来源的食物蛋白

Title:Food Proteins as Source of Opioid Peptides-A Review

Volume: 23 Issue: 9

Author(s): Swati Garg, Kulmira Nurgali, Vijay Kumar Mishra

Affiliation:

关键词: 阿片，肽，阿片受体，酪啡肽，源外啡肽，发酵。

摘要: Traditional opioids, mainly alkaloids, have been used in the clinical management of pain for a number of years but are often associated with numerous side-effects including sedation, dizziness, physical dependence, tolerance, addiction, nausea, vomiting, constipation and respiratory depression which prevent their effective use. Opioid peptides derived from food provide significant advantages as safe and natural alternative due to the possibility of their production using animal and plant proteins as well as comparatively less side-effects. This review aims to discuss the current literature on food-derived opioid peptides focusing on their production, methods of detection, isolation and purification. The need for screening more dietary proteins as a source of novel opioid peptides is emphasized in order to fully understand their potential in pain management either as a drug or as part of diet complementing therapeutic prescription.

Cite this article as:

Swati Garg, Kulmira Nurgali, Vijay Kumar Mishra , Food Proteins as Source of Opioid Peptides-A Review, Current Medicinal Chemistry 2016; 23 (9) . https://dx.doi.org/10.2174/0929867323666160219115226