靶向细菌双组分系统对囊性纤维化病人抗菌治疗的理论和展望

Title:Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients

Volume: 18 Issue: 6

关键词: 细菌感染，囊性纤维化，双组分系统，抗菌治疗，呼吸道感染，病原体。

摘要: Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkholderia cepacia complex and especially Pseudomonas aeruginosa are more frequently seen. P. aeruginosa is a turning point in the respiratory disease in CF and its predominance increases with age. Bacteria use a variety of two-component systems (TCS) to differentially express virulence factors involved in both acute and chronic infections. Here, we review bacterial TCS as targets for antibacterial treatment for CF patients.

Cite this article as:

Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients, Current Drug Targets 2017; 18 (6) . https://dx.doi.org/10.2174/1389450117666160208145934