Abstract
It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
Keywords: endogenous modulatory
Current Neurovascular Research
Title: Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain
Volume: 1 Issue: 1
Author(s): Daphne A. Robinson, Amelita A. Calejesan, Feng Wei, Gerald F. Gebhart and Min Zhuo
Affiliation:
Keywords: endogenous modulatory
Abstract: It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
Export Options
About this article
Cite this article as:
Robinson A. Daphne, Calejesan A. Amelita, Wei Feng, Gebhart F. Gerald and Zhuo Min, Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain, Current Neurovascular Research 2004; 1 (1) . https://dx.doi.org/10.2174/1567202043480189
DOI https://dx.doi.org/10.2174/1567202043480189 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Monoamine Oxidase Inhibitors as Neuroprotective Agents in Age-Dependent Neurodegenerative Disorders
Current Pharmaceutical Design Editorial (Thematic Issue: Chemistry Towards Biology: Proceedings of the Katowice Conference)
Current Protein & Peptide Science Antioxidant Properties of Pyrimidine and Uracil Derivatives
Current Organic Chemistry Neuron-Microglia Interaction in Neuroinflammation
Current Protein & Peptide Science Lipid Rafts and Fas/CD95 Signaling in Cancer Chemotherapy
Recent Patents on Anti-Cancer Drug Discovery Cholecystokinin Antagonists A New Way to Improve the Analgesia from Old Analgesics?
Current Pharmaceutical Design Dopamine D<sub>4</sub> Receptor Antagonists for the Treatment of Cocaine Use Disorders
CNS & Neurological Disorders - Drug Targets New Strategies and Patent Therapeutics in EBV-Associated Diseases
Mini-Reviews in Medicinal Chemistry Epilepsy, Comorbidities and Treatments
Current Pharmaceutical Design Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer’s Disease Transgenic Mice
Current Alzheimer Research Psychosocial Implications During Adolescence for Infant Heart Transplant Recipients
Current Cardiology Reviews Mitochondria, Mitochondrial DNA and Alzheimers Disease. What Comes First?
Current Alzheimer Research Effect of the Antifibrillatory Compound Tedisamil (KC-8857) on Transmembrane Currents in Mammalian Ventricular Myocytes
Current Medicinal Chemistry Drug Combinatorial Therapies for the Treatment of KRAS Mutated Lung Cancers
Current Topics in Medicinal Chemistry Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists
Current Medicinal Chemistry Employing New Cellular Therapeutic Targets for Alzheimers Disease: A Change for the Better?
Current Neurovascular Research Editorial (Thematic Issue: Genetics: A Window into the Biology of the Mind)
Current Psychiatry Reviews Patent Selections
Recent Patents on Biomedical Engineering (Discontinued) Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease
Current Alzheimer Research The Effect of Stress Management Program on Perceived Stress in Patients with Type 2 Diabetes: A Randomized Controlled Trial
Current Diabetes Reviews