Abstract
Trifluoromethylated amines, especially optically active ones, are very important synthetic building blocks in the design of bioactive products. Over the past decades, the development of highly efficient methods for asymmetric synthesis of Trifluoromethylated amines and their derivatives has attracted a continuing interest. A brief overview will give an insight into the asymmetric synthesis of trifluoromethylated amines and their derivatives from trifluoromethyl imines, nucleophilic trifluoromethylation tamed, fluorine-containing allylic esters, and by enzymatic catalysis.
Keywords: Trifluoromethylated amines, asymmetric synthesis, nucleophilic addition, hydrogenation.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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