Background: Advances in preparatory and analytical technology have greatly contributed to the maturing of metabolomics research over the past decade. Despite this, specific limitations in sample preparation and analysis remain unresolved within the field. More importantly, post-metabolomic application or commercialization of discovered biomarkers is also scarce because of the lack of simplified analytical techniques to measure these markers in the clinic or industry.
Focus: Nanotechnology can address many of these limitations and provide innovative solutions for metabolomics sample preparation and analysis through compound entrapment technology and nanoparticle-assisted ionization. Moreover, the creative development of biosensors can advance the application and/or commercialization of discovered biomarkers. This innovative use of nanotechnology in metabolomics research and biomarker application is the focus of this paper.
Prospect: The use of existing nanotechnology in analytics is reviewed and inspirational new concepts to improve metabolomics research are discussed as a means to encourage researchers of both fields to collaborate and innovate.
Keywords: Analytical technology, biosensors, compound entrapment, metabolomics, mass spectrometry, nanotechnology.