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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Progress in the Use of Autologous Regenerative Platelet-based Therapies in Implant Dentistry

Author(s): Eduardo Anitua, María Troya, Mar Zalduendo, Ricardo Tejero and Gorka Orive

Volume 17 , Issue 5 , 2016

Page: [402 - 413] Pages: 12

DOI: 10.2174/1389201017666160127110300

Price: $65


The field of medicine is rapidly moving towards the development of personalized treatments and non-invasive tools to achieve a more predictable and optimal tissue regeneration. In this sense, the goal of periodontal healing is to arrest disease progression and functionally regenerate all the tissues that comprise the periodontium. The latter implies a well-orchestrated interaction among oral cells, growth factors and extracellular matrix. Although several procedures are performed in an attempt to regenerate lost periodontal tissue, outcomes are not always predictable. Growth factors represent a class of biologically active polypeptides that have a critical role in the healing process. Their use provides a new paradigm to understand the regenerative medicine. The use of platelet- rich plasma (PRP) products as a local source and delivery system of autologous growth factors has emerged recently. Among them, PRGF stands for its remarkable stimulatory effect on oral tissue regeneration, making it a very safe and successful tool with a great value in Dentistry.

Keywords: Growth factors, platelet rich plasma, gingival fibroblast, periodontal ligament, alveolar osteoblasts and implant surface.

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