Azetidin-2-ones, Synthon for Biologically Important Compounds †

Title: Azetidin-2-ones, Synthon for Biologically Important Compounds †

Volume: 11 Issue: 14

Author(s): A.R. A.S. Deshmukh, B. M. Bhawal, D. Krishnaswamy, Vidyesh V. Govande, Bidhan A. Shinkre and A. Jayanthi

Affiliation:

Keywords: Azetidin-2-ones, polyamines, peptides, synthon

Abstract: Azetidin-2-one, a four-membered cyclic lactam (β-lactam) skeleton has been recognised as a useful building block for the synthesis of a large number of organic molecules by exploiting the strain energy associated with it, in addition to its use in the synthesis of a variety of β-lactam antibiotics. Efforts have been made in exploring such new aspects of β-lactam chemistry using enantiomerically pure β-lactams as versatile intermediates for the synthesis of aromatic β-amino acids and their derivatives, peptides, polyamines, polyamino alcohols, amino sugars and polyamino ethers. The development of methodologies based on β- lactam nucleus is now referred as the β-lactam synthon methods. The selective bond cleavage of the strained ring coupled with further interesting transformation render this fascinating molecule as a powerful building block. This provides an access to diverse structural type of synthetic target molecules lacking β-lactam ring structure. This review provides an account of synthesis of organic compounds having biological significance at the same time lacking β-lactam ring, by using β-lactam as synthon.

Cite this article as:

Deshmukh A.S. A.R., Bhawal M. B., Krishnaswamy D., Govande V. Vidyesh, Shinkre A. Bidhan and Jayanthi A., Azetidin-2-ones, Synthon for Biologically Important Compounds †, Current Medicinal Chemistry 2004; 11 (14) . https://dx.doi.org/10.2174/0929867043364874