Abstract
The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensively expressed in vertebrates, vertebrate-infecting parasites and higher plants, where they are often involved in chromatin remodeling, methylation recognition, epigenetic regulation and early embryonic development. Since the first CW domain structure was determined 5 years ago, structures of five CW domains have been solved so far. In this review, we will discuss these recent advances in understanding the identification, definition, structure, and functions of the CW domain containing proteins.
Keywords: CW domain, epigenetic regulation, transcription, early embryonic development.
Current Protein & Peptide Science
Title:Structure and Function of CW Domain Containing Proteins
Volume: 17 Issue: 5
Author(s): Yanli Liu, Shasha Liu, Xinxin Zhang, Xiao Liang, Kashif Rafiq Zahid, Ke Liu, Jinlin Liu, Lingfu Deng, Jihong Yang and Chao Qi
Affiliation:
Keywords: CW domain, epigenetic regulation, transcription, early embryonic development.
Abstract: The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensively expressed in vertebrates, vertebrate-infecting parasites and higher plants, where they are often involved in chromatin remodeling, methylation recognition, epigenetic regulation and early embryonic development. Since the first CW domain structure was determined 5 years ago, structures of five CW domains have been solved so far. In this review, we will discuss these recent advances in understanding the identification, definition, structure, and functions of the CW domain containing proteins.
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Cite this article as:
Liu Yanli, Liu Shasha, Zhang Xinxin, Liang Xiao, Rafiq Zahid Kashif, Liu Ke, Liu Jinlin, Deng Lingfu, Yang Jihong and Qi Chao, Structure and Function of CW Domain Containing Proteins, Current Protein & Peptide Science 2016; 17 (5) . https://dx.doi.org/10.2174/1389203717666160125115130
DOI https://dx.doi.org/10.2174/1389203717666160125115130 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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