摘要
多元不饱和脂肪酸(PUFA)对我们的健康和福祉至关重要;因此,他们已经被广泛地研究在维护人类健康和疾病治疗中究竟扮演着什么角色。大多数西方的饮食中含有大量饱和脂肪和ω-6脂肪酸及不足量的ω-3脂肪酸;然而,特别是ω-3和ω-6多元不饱和脂肪酸之间的平衡,对形成促炎和抗炎脂质以促进健康和预防疾病至关重要。作为我们的日常饮食中影响我们的健康,本文提请注意ω-3脂肪酸组的唯一代表:α-亚麻酸及其衍生物。最近,这已被证明对治疗和预防各种疾病有效。已证实,ω-3多元不饱和脂肪酸也可作为治疗剂以及其对炎症性疾病有重要的作用。如已被阐述了的心血管疾病和神经退行性疾病。一些营养因素已被描述为重要的改性剂,可影响大脑的弹性,因此,对中枢神经系统功能具有影响。因此,适当的膳食管理似乎能成为抵消神经和认知障碍的一种非侵入性的和有效的方法。
关键词: α-亚麻酸,ALA,血脑屏障,中枢神经系统,必需脂肪酸,亚油酸,多不饱和脂肪
Current Medicinal Chemistry
Title:Omega-3 Fatty Acids and their Role in Central Nervous System - A Review
Volume: 23 Issue: 8
Author(s): Tomasz Wysoczański, Ewa Sokoła-Wysoczańska, Jolanta Pękala, Stanisław Lochyński, Katarzyna Czyż and Robert Bodkowski, Grzegorz Herbinger, Bożena Patkowska-Sokoła, Tadeusz Librowski
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关键词: α-亚麻酸,ALA,血脑屏障,中枢神经系统,必需脂肪酸,亚油酸,多不饱和脂肪
摘要: Polyunsaturated fatty acids (PUFAs) are crucial for our health and wellbeing; therefore, they have been widely investigated for their roles in maintaining human health and in disease treatment. Most Western diets include significant amount of saturated and omega-6 fatty acids and insufficient quantity of omega-3; however, the balance between omega-6 and omega-3 PUFA, in particular, is essential for the formation of pro- and anti-inflammatory lipids to promote health and prevent disease. As our daily diet affects our health, this paper draws attention to unique representatives of the omega-3 fatty acid group: alpha-linolenic acid and its derivatives. Recently, this has been shown to be effective in treating and preventing various diseases. It has been confirmed that omega-3 PUFAs may act as therapeutic agents as well and their significant role against inflammatory diseases, such as cardiovascular and neurodegenerative diseases, has been described. Some of nutritional factors have been described as a significant modifiers, which can influence brain elasticity and thus, effect on central nervous system functioning. Therefore, appropriate dietary management appears to be a non-invasive and effective approach to counteract neurological and cognitive disorders.
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Tomasz Wysoczański, Ewa Sokoła-Wysoczańska, Jolanta Pękala, Stanisław Lochyński, Katarzyna Czyż and Robert Bodkowski, Grzegorz Herbinger, Bożena Patkowska-Sokoła, Tadeusz Librowski , Omega-3 Fatty Acids and their Role in Central Nervous System - A Review, Current Medicinal Chemistry 2016; 23 (8) . https://dx.doi.org/10.2174/0929867323666160122114439
DOI https://dx.doi.org/10.2174/0929867323666160122114439 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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