Abstract
Numerous diseases affect the respiratory tract and the aerosol administration has been widely considered as an adapted and non-invasive method for local delivery. This pathway induces a lung concentration and thus also limits, systemic side effects. However, aerosol delivery of active pharmaceutical ingredients represents a real challenge, due to numerous obstacles such as the specific respiratory movement, the presence of mucus or surfactant, and the mucociliary clearance. Nanomedicines, such as liposomes, micelles or nanoparticles, offer the possibility to increase bioavailability and favor intracellular penetration of specific drugs into lung tissue. This review focuses on the description of aerosol formulations and cellular barriers including design, characteristics and progressive adaptation to airways anatomy. Then, aerosolized formulations currently clinically approved, or in clinical trial are summarized according to the encapsulated drug. In a final section, promising aerosol formulations in pre-clinical studies are detailed.
Keywords: Nanomedicines, Nebulization, Inhaled, Antibiotics, Chemotherapy, Plasmid.
Current Gene Therapy
Title:Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways
Volume: 16 Issue: 1
Author(s): P. Resnier, A. Mottais, Y. Sibiril, T. Le Gall and T. Montier
Affiliation:
Keywords: Nanomedicines, Nebulization, Inhaled, Antibiotics, Chemotherapy, Plasmid.
Abstract: Numerous diseases affect the respiratory tract and the aerosol administration has been widely considered as an adapted and non-invasive method for local delivery. This pathway induces a lung concentration and thus also limits, systemic side effects. However, aerosol delivery of active pharmaceutical ingredients represents a real challenge, due to numerous obstacles such as the specific respiratory movement, the presence of mucus or surfactant, and the mucociliary clearance. Nanomedicines, such as liposomes, micelles or nanoparticles, offer the possibility to increase bioavailability and favor intracellular penetration of specific drugs into lung tissue. This review focuses on the description of aerosol formulations and cellular barriers including design, characteristics and progressive adaptation to airways anatomy. Then, aerosolized formulations currently clinically approved, or in clinical trial are summarized according to the encapsulated drug. In a final section, promising aerosol formulations in pre-clinical studies are detailed.
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Cite this article as:
Resnier P., Mottais A., Sibiril Y., Gall Le T. and Montier T., Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways, Current Gene Therapy 2016; 16 (1) . https://dx.doi.org/10.2174/1566523216666160104142013
DOI https://dx.doi.org/10.2174/1566523216666160104142013 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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