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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism

Author(s): Nóra Török, Zsófia Majláth, Ferenc Fülöp, József Toldi and László Vécsei

Volume 17, Issue 5, 2016

Page: [412 - 429] Pages: 18

DOI: 10.2174/1389200217666151222155043

Price: $65

Abstract

Introduction: The kynurenine pathway includes several neuroactive compounds, including kynurenic acid, picolinic acid, 3-hydroxykynurenine and quinolinic acid. The enzymatic cascade of the kynurenine pathway is tightly connected with the immune system, and may provide a link between the immune system and neurotransmission.

Main Areas Covered: Alterations in this cascade are associated with neurodegenerative, neurocognitive, autoimmune and psychiatric disorders, such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, migraine or schizophrenia.

Highlights: This review highlights the alterations in this metabolic pathway in the physiological aging process and in different disorders. A survey is also presented of therapeutic possibilities of influencing this metabolic route, which can be achieved through the use of synthetic kynurenic acid analogues, enzyme inhibitors or even nanotechnology.

Keywords: Aging, Alzheimer’s disease, amyotrophic lateral sclerosis, glutamate excitotoxicity, Huntington’s disease, kynurenine pathway, migraine, multiple sclerosis, neurodegeneration, neuroprotection, Parkinson’s disease, picolinic acid, schizophrenia, Toxoplasma gondii.


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