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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Synthesis of Ethyl Octyl-α-Aminophosphonate Derivatives

Author(s): Ádám Tajti, Erika Bálint and György Keglevich

Volume 13, Issue 4, 2016

Page: [638 - 645] Pages: 8

DOI: 10.2174/1570179413666151218202757

open access plus


Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was prepared, and utilized in the Kabachnik–Fields reaction. The condensation of EOP, paraformaldehyde and primary or secondary amines used in equimolar quantities afforded new α-aminophosphonates under microwave conditions. Methylation of the -α(alkylamino)phosphonates was also investigated. The double phospha-Mannich reaction of primary amines and two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.

Keywords: Ethyl octyl phosphite, Kabachnik–Fields reaction, Ethyl octyl α-aminomethyl-phosphonates, N, N-Bis(ethyloctylphosphonoylmethyl) amines, Microwave.

Graphical Abstract

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