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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Microwave-Assisted Biginelli Reaction: An Old Reaction, a New Perspective

Author(s): Majid M. Heravi, Mahdieh Ghavidel and Bahareh Heidari

Volume 13, Issue 4, 2016

Page: [569 - 600] Pages: 32

DOI: 10.2174/1570179413666151218202307

open access plus


In this review, we tried to highlight the recent advances in the Biginelli reaction, leading to the synthesis of 3,4-dihydropyrimidin-2(1H)-ones, albeit only those conducted under microwave irradiation. The merits and drawbacks of these reactions are compared and discussed with those performed under conventional heating.

Dedicated to kazem Kargosha, in the occasion of his honorable retirement as a Professor in Analytical Chemistry. I would like to open this essay by paying homage to Professor Kargosha, who was much inspirational to the establishment of the Iranian Chemical &Chemical Engineering Society (then, Iranian Chemical Society).

Keywords: Biginelli reaction, dihydropyrimidines, DHPMs microwave irradiation, brønsted acid, lewis acid, ionic liquid, catalysis, multicomponent reactions, (MCRs).

Graphical Abstract

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