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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

Author(s): Amna M. Abdella, Ahmed H. M. Elwahy and Ismail A. Abdelhamid

Volume 13, Issue 4, 2016

Page: [601 - 610] Pages: 10

DOI: 10.2174/1570179413999151211115100

Price: $65


An efficient and convenient route for synthesis of novel bis 4H-chromene-3- carbonitrile derivatives is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated.

Keywords: Bis-aldehydes, bis-arylidenemalononitriles, multicomponent reactions, Bis-4H-chromene-3-carbonitriles.

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