Abstract
Colorectal cancer is the third most common type of cancer in both, men and women. The development of metastasis is very frequent, especially in patients with advanced stage, who require intensive chemotherapy that often results in poor response and significant morbidity. The undesirable effects of intensive chemotherapy on normal cells and the development of multidrug resistance are two of the main causes of treatment failure. Recent advances in nanotechnology allow to target cancer cells using cytotoxic drugs without affecting normal cells. Nanocarriers such as liposomes, polymeric nanoparticles and carbon nanotubes, among others, are able to improve drug distribution and bioavailability, cytotoxic concentration in the tumor mass and drug delivery to tumor tissue and, at the same time, reduce side effects. Current research studies are being conducted to develop new biomaterials that improve the characteristics of these nanomolecules. Several preclinical assays have disclosed the efficacy of nanotherapy in colon cancer, although further clinical trials will be necessary to demonstrate its efficacy. This review discusses the current status and the potential advantages of using nanocarrier-based drug delivery systems for colorectal cancer.
Keywords: Carbon nanotubes, colon cancer, drug delivery, liposomes, nanoparticles, polymeric nanoparticles.
Current Drug Delivery
Title:Last Advances in Nanocarriers-Based Drug Delivery Systems for Colorectal Cancer
Volume: 13 Issue: 6
Author(s): Ana R. Rama, Julia Jimenez-Lopez, Laura Cabeza, Cristina Jimenez-Luna, Maria C. Leiva, Gloria Perazzoli, Rosa Hernandez, Inmaculada Zafra, Raul Ortiz, Consolacion Melguizo and Jose Prados
Affiliation:
Keywords: Carbon nanotubes, colon cancer, drug delivery, liposomes, nanoparticles, polymeric nanoparticles.
Abstract: Colorectal cancer is the third most common type of cancer in both, men and women. The development of metastasis is very frequent, especially in patients with advanced stage, who require intensive chemotherapy that often results in poor response and significant morbidity. The undesirable effects of intensive chemotherapy on normal cells and the development of multidrug resistance are two of the main causes of treatment failure. Recent advances in nanotechnology allow to target cancer cells using cytotoxic drugs without affecting normal cells. Nanocarriers such as liposomes, polymeric nanoparticles and carbon nanotubes, among others, are able to improve drug distribution and bioavailability, cytotoxic concentration in the tumor mass and drug delivery to tumor tissue and, at the same time, reduce side effects. Current research studies are being conducted to develop new biomaterials that improve the characteristics of these nanomolecules. Several preclinical assays have disclosed the efficacy of nanotherapy in colon cancer, although further clinical trials will be necessary to demonstrate its efficacy. This review discusses the current status and the potential advantages of using nanocarrier-based drug delivery systems for colorectal cancer.
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Rama R. Ana, Jimenez-Lopez Julia, Cabeza Laura, Jimenez-Luna Cristina, Leiva C. Maria, Perazzoli Gloria, Hernandez Rosa, Zafra Inmaculada, Ortiz Raul, Melguizo Consolacion and Prados Jose, Last Advances in Nanocarriers-Based Drug Delivery Systems for Colorectal Cancer, Current Drug Delivery 2016; 13 (6) . https://dx.doi.org/10.2174/1567201813666151203232852
DOI https://dx.doi.org/10.2174/1567201813666151203232852 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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