Abstract
Natural products, especially bioactive molecules as drug lead compounds, have attracted extensive attention in health promotion and in drug discovery and development. It is essential to understand the structures and functional mechanisms of these lead molecules prior to drug development. This review provides comprehensive information for more than 130 newly reported peroxides appeared in the literature in the recent years. The compounds are natural peroxides with bioactivities. While some of them appeared in previous reviews, a great number of newly-found natural peroxides with up-dated information are extensively reviewed in this article, which focuses on the biological activities based on various structural classes including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids and steroidal peroxy compounds isolated from terrestrial and marine sources. These natural peroxides are valuable sources in drug discovery with antitumor and antimalarial activities.
Keywords: Natural peroxide, endoperoxide, antimalarial peroxides, artemisinin, steroids, anticanceragent.
Current Medicinal Chemistry
Title:Natural Endoperoxides as Drug Lead Compounds
Volume: 23 Issue: 4
Author(s): Ming Bu, Burton B. Yang and Liming Hu
Affiliation:
Keywords: Natural peroxide, endoperoxide, antimalarial peroxides, artemisinin, steroids, anticanceragent.
Abstract: Natural products, especially bioactive molecules as drug lead compounds, have attracted extensive attention in health promotion and in drug discovery and development. It is essential to understand the structures and functional mechanisms of these lead molecules prior to drug development. This review provides comprehensive information for more than 130 newly reported peroxides appeared in the literature in the recent years. The compounds are natural peroxides with bioactivities. While some of them appeared in previous reviews, a great number of newly-found natural peroxides with up-dated information are extensively reviewed in this article, which focuses on the biological activities based on various structural classes including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids and steroidal peroxy compounds isolated from terrestrial and marine sources. These natural peroxides are valuable sources in drug discovery with antitumor and antimalarial activities.
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Cite this article as:
Bu Ming, Yang B. Burton and Hu Liming, Natural Endoperoxides as Drug Lead Compounds, Current Medicinal Chemistry 2016; 23 (4) . https://dx.doi.org/10.2174/0929867323666151127200949
DOI https://dx.doi.org/10.2174/0929867323666151127200949 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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