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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

1-Hydroxypyranonaphthoquinones – Isolation, Bioactivity and Synthesis

Author(s): Christopher D. Donner

Volume 12, Issue 5, 2015

Page: [397 - 413] Pages: 17

DOI: 10.2174/1570193X13666151125230909

Price: $65

Abstract

A discussion of 1-hydroxypyranonaphthoquinones is presented that outlines the isolation and biological activity of the known naturally occurring members of this class of compounds. Synthetic approaches developed towards 1- hydroxypyranonaphthoquinones and analogues having potentially improved biological profiles are discussed with particular emphasis on the HRV 3C-protease inhibitor thysanone.

Keywords: 1-hydroxy-1H-benzo[g]isochromene, 1-hydroxy-1H-naphtho[2, 3-c]pyran, fungal pigment, HRV 3C-protease, lactol, naphthopyran, pyranonaphthoquinone, thysanone.

Graphical Abstract

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