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Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Nitric Oxide Synthases and Their Natural Inhibitors

Author(s): Christos Kontogiorgis and Dimitra Hadjipavlou-Litina

Volume 12 , Issue 1 , 2016

Page: [3 - 15] Pages: 13

DOI: 10.2174/1573408012666151126185628

Price: $65

Sekisui-XenoTech-CEI
Abstract

Nitric Oxide (NO) is a molecule of extreme interest to biologists, pharmacologists, physiologists, and biochemists, characterized as a mediator in the cardiovascular system. It has been found to be implicated in various pathological processes. NO is synthesized enzymatically by Nitric Oxide Synthases (NOSs) from L-arginine, and therefore NOSs have emerged as very crucial therapeutic targets. Herein, a series of extracts from plants as well as a number of isolated compounds acting as NOS inhibitors are presented.

Keywords: Nitric oxide synthase inhibitors, naturally occurring NOS inhibitors, NOS inhibitors from plants, isolated natural compounds, extracts from plants.


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