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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Vascular effects of flavonoids

Author(s): Bruno Almeida Rezende, Aline Carvalho Pereira, Steyner F. Cortes and Virginia Soares Lemos

Volume 23 , Issue 1 , 2016

Page: [87 - 102] Pages: 16

DOI: 10.2174/0929867323666151111143616

Price: $65


Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.

Keywords: Cardiovascular system, flavonoids, mechanism, natural products, signaling pathway, vascular effects, vasorelaxation.

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